Methotrexate works best if each dose is taken at the scheduled time.
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The dosage of methotrexate prescribed to each patient will vary.
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The maximum tolerated doses of methotrexate may be lower in elderly patients.
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Serious neurotoxicity, frequently manifested as generalized or focal seizures, has been reported with unexpectedly increased frequency among pediatric patients with acute lymphoblastic leukemia who were treated with intermediate-dose intravenous methotrexate 1 gm m see warnings and precautions .
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Not everyone with rheumatoid arthritis responds favorably to treatment with methotrexate, but multiple studies and reviews showed that the majority of people receiving methotrexate for up to one year had less pain, functioned better, had fewer swollen and tender joints, and had less disease activity overall as reported by themselves and their doctors.
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